Effect of Dieda Ointment on Bone Morphogenetic Protein-2/Suppressor of Mothers Against Decapentaplegic 1/Runt-Related Transcription Factor 2/Sp7 Transcription Factor Pathway for Fracture Healing in Rats

Dieda ointment, a Chinese medicine, has been widely used in the clinical treatment of fracture after years research to prove that it significant effects on healing injury and relieving pain, reinforcing tendons setting bones. However, mechanism its is still unclear. The purpose this study was explore ointment promoting healing. materials methods explored were establish model Sprague-Dawley rats, which externally applied with for 1, 2 4 w imaging examination site performed. Histological also Western blotting quantitative reverse transcription polymerase chain reaction detect expression proteins messenger ribonucleic acid. We found can effectively accelerate callus formation at tibia fractures rats increase acid protein levels bone morphogenetic protein-2, suppressor mothers against decapentaplegic runt-related factor Sp7 factor, regulate promote healing, not only provides theoretical experimental basis subsequent ointment.